Hiperkeratoza je sprememba večinoma nad površino kože in gre za zadebelitev rožene plasti vrhnjice (to je plast vrhnjega dela kože, ki nam daje največjo zaščito pred zunanjimi dejavniki, ter nas ščiti pred vdorom tujih snovi v kožo). Na stopalih in dlaneh imamo v vrhnjici še eno plast kože (stratum lucidum), ki nam daje zaščito pred mehanskimi pritiski). Tudi ta plast se ob večjih mehanskih pritiskih zadebeli. Navadno se ta pojavi zaradi dolgotrajnejših pritiskov na isto mesto, oziroma ponavljajočih se pritiskov, pride do zmanjšane cirkulacije in povečane debeline rožene plasti kože. Do hiperkeratoze pride najpogosteje na peti, saj pri hoji prva pride v stik s podlago in se tako nanjo vrši n
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